Pioneering Regenerative Medicine
Without Immunosuppression

We are a data-driven and patient-centric regenerative medicine company working to enable implantable tissue, organoid or cell therapy without the requirement for life-long immunosuppression. Leveraging our proprietary technology platform, we are advancing a pipeline of product candidates that have the potential to cure diseases.

Pioneering Regenerative Medicine
Without Immunosuppression

We are a data-driven and patient-centric regenerative medicine company working to enable implantable tissue, organoid or cell therapy without the requirement for life-long immunosuppression. Leveraging our proprietary technology platform, we are advancing a pipeline of product candidates that have the potential to cure diseases.

iTOL-100:

Biotechnology-Derived Protein Inducing
Immune Tolerance Platform

iTOL-100 is a synthetic form of the naturally occurring protein, FasL, combined with a synthetic hydrogel microparticle (microgel) that allows convenient and effective co-administration with implanted cells or organoids to induce local immune tolerance without the need for life-long immunosuppression.

iTOL-100:

Biotechnology-Derived Protein Inducing
Immune Tolerance Platform

iTOL-100 is a synthetic form of the naturally occurring protein, FasL, combined with a synthetic hydrogel microparticle (microgel) that allows convenient and effective co-administration with implanted cells or organoids to induce local immune tolerance without the need for life-long immunosuppression.

Developing a Potential Cure for Type 1 Diabetes

Our lead program iTOL-101 is being developed as a potential cure for Type 1 Diabetes. Using our proprietary biotechnology-derived protein therapy platform, iTOL-100, allogenic pancreatic islets are co-implanted and in preclinical studies have shown immune acceptance and long-term function of the graft with control of blood glucose levels and restoration of insulin secretion. Our follow-on candidate, iTOL-102 is leveraging significant advancements in stem cells, which allows an inexhaustible supply of insulin-producing cells for use in Type 1 Diabetes.

Development Pipeline

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