Developing a Potential Treatment for Liver Failure

Current approaches to liver implantation require life-long immunosuppression. The advent of expanding liver cells (known as hepatocytes) to treat liver failure using donated liver organs or stem cell-derived organoids, which function like liver cells have the potential to be greatly enhanced if life-long immunosuppression could be eliminated.

Ongoing Research Collaboration with LyGenesis to Regrow Functioning, Ectopic Livers Without the Need for Immune Suppression

The joint research collaboration has generated in vitro data with iTOL-201 and is now progressing toward small animal proof of concept work to evaluate the combined technology’s potential to produce ectopic livers capable of rescuing the animals from otherwise fatal liver disease without the need for immune suppression.