iTOL-100

Potentially Transformational Regenerative Biotechnology-Derived Protein Therapy Platform

What is Regenerative Medicine?

A class of medicines that aim to grow, repair or replace damaged or diseases cells, tissues or organs. Regenerative medicine goes beyond treating diseases or managing symptoms and seeks to develop cures. However, a significant shortcoming of cell therapy is the body’s immune system working to seek out and kill foreign cells, tissues, organoids and organs implanted into the body, requiring the need for life-long immunosuppression.

 

iTOL-100: Our Biotechnology-Derived Protein Inducing Immune Tolerance Platform

Through a data-driven approach, we are working to enable regenerative medicine without the need for life-long immunosuppression. Our platform technology, iTOL-100, leverages the naturally occurring protein, Fas Ligand (FasL) which is present in all mammals and functions as a natural way for the body to establish local immune tolerance.

iTOL-100 is a biotechnology derived pharmaceutical product, a chimeric fusion protein of streptavidin-FasL in a synthetic biomaterial microgel synthesized through a straightforward process. Ordinarily, activated T-cells will reject foreign tissue.  Current implantation of cells or organs require life-long immunosuppression to prevent organ rejection.  However, when we then mix iTOL-100 with the target cell therapy and implant it into the body, the FasL binds to the Fas receptor (FasR) on activated T-cells, preventing rejection through a process called apoptosis (or programmed cell death). In parallel, T-regulatory cells are generated creating localized immune privilege and protecting the implanted cell therapy.

 

In preclinical studies, our iTOL-100 platform has been shown to establish durable, localized immune tolerance, allowing the implanted tissue, organoid or cell therapy to function as a replacement for damaged native cells.

Mechanism
of Action

 

 Immobilized and
co-localized FasL

Our proprietary technology has broad applicability and can be applied to both allogenic and stem cells across a number of diseases.

A potential cure for
Type 1 Diabetes

Liver failure

Regenerative protein and
cell therapy for diseases
with high unmet need