About Us

iTolerance is a privately held regenerative medicine company developing technologies to enable tissue, organoid or cell therapy without the need for life-long immunosuppression. Leveraging its proprietary biotechnology-derived Strepavidin-FasL fusion protein/biotin-PEG microgel (SA-FasL microgel) platform technology, iTOL-100, iTolerance is advancing a pipeline of programs that have the potential to cure diseases. The Company’s lead program, iTOL-102 is intended to combine iTOL-100 technology with an inexhaustible supply of insulin producing allogeneic stem cell-derived pancreatic islets and is being developed as a potential cure for Type 1 Diabetes.  In a pre-clinical non-human primate study, pancreatic islet cells co-implanted with SA-FasL microgel (now known as iTOL-100) exhibited long-term function with control of blood glucose levels and restoration of insulin secretion without the use of chronic immune suppression. Additionally, the Company is developing iTOL-201 for liver failure and iTOL-401 as a nanoparticle formulation for large organ transplant without the need for life-long immunosuppression.

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